In late 2023, Upside Foods announced their intention of establishing a production facility in Glenview, IL. planned to produce 30 million pounds of cell-cultured meat annually. The plant extending over 187,000 square feet would have cost $140 million and employed 75 workers. Press reports indicate that since 2015 Upside Foods and its predecessor, Memphis Meats attracted $600 million in venture capital support.
Following the announcement of the intended production facility, Upside Foods was subject to negative publicity with disclosures that commercial production of cell-cultured meat could not be consistently achieved using large bioreactors installed in the Emeryville, CA plant. Allegations from existing and ex-employees confirmed failure to scale-up production from laboratory-level plastic roller bottles to bioreactors, in common with many potential producers of cell-cultured meat and poultry.
According to Wired, Upside Foods has apparently laid off workers that were to be involved in planning and construction of the Glenview facility and that expansion at Emeryville will now proceed. Upside Foods now claim that problems previously limiting commercial production have been resolved. Given previous hype and misleading 
statements this will only be confirmed when cell-cultured product appears in supermarket display coolers.
Press reports suggest that investment in cell-cultured meat startups and existing operations has undergone a sharp reduction with growing disillusionment of their ability to produce on a commercial scale, in addition to regulatory hurdles, restrictive labeling legislation and indications of potential consumer rejection.